We recently showed that IL-4, a T-cell-derived cytokine, is a critical participant
in higher brain functions such as memory and learning (5).
我們最近發現,IL-4(一種T細胞衍生的細胞因子)是高級大腦功能(如記憶和學習)
的關鍵參與者(5)。
Mice lacking IL-4 demonstrate cognitive impairment in spatial learning tasks,
and this can be reversed by transplantation of IL-4-competent bone marrow (5).
缺乏IL-4的小鼠在空間學習任務中表現出認知障礙,可以通過移植具有IL-4能力的骨髓來逆轉(5)。
Regulation of learning and memory by meningeal immunity: a key role for IL-4
腦膜免疫調節學習和記憶:IL-4的關鍵作用
Strikingly, IL-4−/− mice exhibited a skewed proinflammatory meningeal myeloid phenotype
and cognitive impairment reminiscent of that seen in T cell–depleted mice,
and was reversed by injection of wild-type T cells.
令人驚訝的是,IL-4缺乏小鼠表現出偏斜的促炎性腦膜髓樣表型及認知損害。