The decrease in transcription of cytokines TNF-α and IFN-γ, and the unprecedented increase in IL-5, as evidenced by Tani et al. [20], appears to be due to Th2 lymphocyte overexpression in the presence of Demodex [59]. 

Tani等人證明，細胞因子TNF-α和IFN-γ的轉錄減少，以及IL-5的空前增加。 [20]，

似乎是由於在蠕形蟎存在下Th2淋巴細胞過表達[59]。

節錄自https://www.intechopen.com/books/parasitology-and-microbiology-research /clinical-and-immuno-pathology-aspects-of-canine-demodicosis

Reduced TLR6 expression could be helping Demodex mites to proliferate.

TLR6表達降低可能有助於蠕形蟎滋生。

節錄自https://www.sciencedirect.com/science/article/abs/pii/S0304401720300431

Further, TLR6 is moderately upregulated by autocrine IFN-gamma, IL-1 beta.

此外，TLR6被自分泌IFN-γ，IL-1β適度上調。

節錄自https://www.rndsystems.com/resources/articles/toll-receptor-family

TLR6_G1083C (synonymous) were associated with increased IFN-γ, 

TLR6_G1083C and TLR6_C745T were associated with increased IL-2

For each of these polymorphisms, the hypo-responsive allele, as defined by 

innate immunity signaling assays, was associated with increased production 

of TH1-type T cell cytokines (IFN-γ or IL-2).

對於這些多態性中的每一個，通過先天免疫信號分析確定的低反應性等位基因與TH1型T細胞細胞因子（IFN-γ或IL-2）產生的增加有關。

節錄自https://www.prolekarniky.cz/casopisy/plos-pathogens/2011-8 /association-of-human-tlr1-and-tlr6-deficiency-with-altered-immune -responses-to-bcg-vaccination-in-south-african-infants-46147

【TH1輔助細胞】主要作用為對抗細胞內細菌及原蟲的免疫反應，